26.12 Red cell folate (categories)
Within reference ranges (360 to 1400 vs >1400).
26.12.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 176.5298310 | 1 | <0.0001 | *** |
| rcfolate_gp | 0.0020879 | 1 | 1.0 | ns |
| GA_samp | 75.7290268 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 41.4726214 | 1 | <0.0001 | *** |
| rcfolate_gp | 0.2775494 | 1 | 0.6 | ns |
| GA_samp | 1126.6013558 | 1 | <0.0001 | *** |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 420.04231 | 1 | <0.0001 | *** |
| rcfolate_gp | 6.18705 | 1 | 0.01 | * |
| GA_samp | 572.93929 | 1 | <0.0001 | *** |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp | 1 | Inf | 0.418 | 0.418 | 0.5 | ns |
| GA_samp | 1 | Inf | 0.761 | 0.761 | 0.4 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp | 1 | Inf | 0.435 | 0.435 | 0.5 | ns |
| GA_samp | 1 | Inf | 0.646 | 0.646 | 0.4 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | |
|---|---|---|---|---|---|---|
| rcfolate_gp | 1 | Inf | 4.135 | 4.135 | 0.04 | * |
| GA_samp | 1 | Inf | 0.457 | 0.457 | 0.5 | ns |
26.12.2 Model summary
Ratio of Geometric means (95% CI)
| Var | Effect | P |
|---|---|---|
| (Intercept) | 14.79 (9.94, 22.00) | <0.0001 |
| rcfolate_gp>1400 | 1.00 (0.90, 1.11) | 0.96 |
| GA_samp | 1.15 (1.12, 1.19) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.98 (1.61, 2.44) | <0.0001 |
| rcfolate_gp>1400 | 1.02 (0.96, 1.08) | 0.60 |
| GA_samp | 1.35 (1.33, 1.37) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.05 (0.04, 0.06) | <0.0001 |
| rcfolate_gp>1400 | 0.90 (0.83, 0.98) | 0.01 |
| GA_samp | 1.35 (1.32, 1.39) | <0.0001 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 8.11 (5.00, 13.13) | <0.0001 |
| rcfolate_gp>1400 | 1.04 (0.92, 1.19) | 0.52 |
| GA_samp | 1.02 (0.98, 1.06) | 0.38 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.71 (1.04, 2.82) | 0.03 |
| rcfolate_gp>1400 | 1.05 (0.91, 1.20) | 0.51 |
| GA_samp | 1.02 (0.97, 1.06) | 0.42 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 4.78 (4.35, 5.25) | <0.0001 |
| rcfolate_gp>1400 | 1.04 (1.00, 1.07) | 0.04 |
| GA_samp | 1.00 (0.99, 1.00) | 0.50 |
26.12.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
26.12.4 Estimated marginal means
| Outcome | rcfolate_gp | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| PRL (ng/ml) | 360 to 1400 | 74.847 | 6.442 | 75.895 | 63.057 | 88.843 |
| PRL (ng/ml) | >1400 | 74.659 | 6.331 | 71.843 | 63.048 | 88.409 |
| hPL (μg/ml) | 360 to 1400 | 61.851 | 2.053 | 74.734 | 57.894 | 66.078 |
| hPL (μg/ml) | >1400 | 62.844 | 2.025 | 67.509 | 58.930 | 67.018 |
| GH2 (ng/ml) | 360 to 1400 | 1.529 | 0.063 | 96.552 | 1.410 | 1.658 |
| GH2 (ng/ml) | >1400 | 1.378 | 0.054 | 85.205 | 1.274 | 1.490 |
| Insulin (uU/ml) | 360 to 1400 | 10.052 | 0.468 | Inf | 9.176 | 11.013 |
| Insulin (uU/ml) | >1400 | 10.498 | 0.504 | Inf | 9.556 | 11.533 |
| HOMA-IR | 360 to 1400 | 2.104 | 0.102 | Inf | 1.913 | 2.314 |
| HOMA-IR | >1400 | 2.204 | 0.112 | Inf | 1.996 | 2.434 |
| Glucose (mmol/L) | 360 to 1400 | 4.648 | 0.056 | Inf | 4.540 | 4.759 |
| Glucose (mmol/L) | >1400 | 4.818 | 0.062 | Inf | 4.698 | 4.941 |
26.12.6 Post-hoc comparisons
| Outcome | Contrast | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|
| PRL (ng/ml) | >1400 / 360 to 1400 | 1.00 (0.90, 1.11) | 1.0 |
| hPL (μg/ml) | >1400 / 360 to 1400 | 1.02 (0.96, 1.08) | 0.6 |
| GH2 (ng/ml) | >1400 / 360 to 1400 | 0.90 (0.83, 0.98) | 0.01 |
| Insulin (uU/ml) | >1400 / 360 to 1400 | 1.04 (0.92, 1.19) | 0.5 |
| HOMA-IR | >1400 / 360 to 1400 | 1.05 (0.91, 1.20) | 0.5 |
| Glucose (mmol/L) | >1400 / 360 to 1400 | 1.04 (1.00, 1.07) | 0.04 |